14 years of thought leadership in user research, experience design, and design ethics

Speaking and Keynotes

Operational Application of AI

CoDesign Collaborative LinkedIn Live Event, Nov 2025

As artificial intelligence becomes more deeply embedded in everyday systems, organizations across sectors are asking how to move from experimentation to responsible, effective use at scale. This discussion explores the operational applications of AI, with an emphasis on real-world challenges, ethical considerations, and opportunities to improve public service and organizational effectiveness.


Building the Plane as it Flies Through a Black Hole: Revising Five UX Research Practices for Generative AI Development

UXPA Boston, May 2025

Samantha shares five critical shifts for evolving traditional UX research into a high-impact, agile practice tailored for the fast-paced and unpredictable landscape of generative AI R&D at IBM.


Designing Better Problems: Research-Led Impact in the More-Than-Human World

Boston Design Week, April 2024

This talk explores how designers can contribute to wildlife conservation by leveraging design research and strategy to bridge the gap between art and science as illustrated by Samantha's seven years of collaboration with the non-profit Creature Conserve.


Playing with our Futures: Enabling Play as an Essential Design Tool for Envisioning Solutions to Serious Problems

Primer21, July 2021

I illustrate how designers can harness the power of play to change our mindsets, collaborations, and processes when envisioning solutions to serious problems.


Design Strategy: Figuring Out What the Heck to Design

Design for Healthcare, June 2020

In this interactive workshop, I share the essential design strategy tools and mindsets tailored for healthcare, guiding participants through the collaborative process of transforming research and assumptions into validated solution concepts through rapid prototyping. View the event.


Ethics in Design: Breaking Down Barriers to Conversation Through Play

World Interaction Design Day 2019

Participants experience first-hand the powerful blend of ethics and game design in this interactive workshop by playing a game that guides them through the collaborative creation of a code of ethics to apply to their real world design practice.


Designing for Health Equity

Better World By Design 2018

This talk explores how designers are uniquely positioned to help all people achieve their fullest potential by focusing on health equity and draws on case studies from Samantha's work at Hennepin County Medical Center.


Root Causes: Overcoming Barriers to Health Equity (Keynote)

Healthcare Refactored Conference 2017

This keynote reframes health equity as a design challenge demanding we look past immediate symptoms to fix the fundamental root causes through inclusive, community-centered co-design.


The Mythology of Plug and Play

Safety Net Innovation Network, May 2017

Drawing on my experience implementing a digital social determinants of health tool within a complex healthcare ecosystem, I explain that successful implementation relies less on the technology and more on cultivating flexible partnerships, prioritizing end-user needs, and maintaining a commitment to continuous impact measurement. Learn More


Community Participation in Healthcare: A Designer’s Inside View of the Link Between Authentic Co-Creation and Health Equity

Association for Community Design 2017

In this talk, I share how designers must move beyond performative community engagement by addressing systemic power imbalances and leveraging transparent co-creation in order to transform healthcare into a true driver of health equity.


Compassion & Inclusion: Participatory Design in Health (Keynote Panel)

Better World by Design 2016

This keynote panel explores the role designers play creating opportunities for patients and care teams alike to co-create the delivery and experience of healthcare.


Designing for Hope & Health

Better World by Design 2016

This talk explores how designers are using co-design methods to redefine health beyond clinical treatment, integrating social determinants and emotional well-being into a more holistic, data-driven vision for the future of care.


The Designer's Oath

SustainableUX 2016

The curators of The Designer’s Oath share the history and motivation behind the Designer's Oath project, a collaborative effort inspired by the Hippocratic Oath to highlight the importance of ethics in designers' practices as our influence expands to impact both people and the planet.


Design for Good: Collaboratively Defining Designers’ Codes of Ethics

Interaction Design Association 2016

This workshop applies game mechanics to ethical conversation using a roleplaying design ethics game that allows participants to experience tough ethical situations, define their personal ethical stance, and learn strategies for discussing ethics in a group environment. Learn more.


The Designer's Oath

Mayo Clinic Transform 2015

This PechaKucha-style talk introduces the "Designers' Oath", a tool to establish ethical guidelines for multidisciplinary design teams, emphasizing the importance of collaborative conversations to ensure desigers "do only good".


Collecting Visual Patient Narratives

Graphic Medicine 2014

This talk explains how to bridge the gap between clinical data and the human experience using the Visual Patient Narrative Kit. This Kit empowers patients to share their stories through non-linear visual tools, uncovering essential insights that drive meaningful improvements in healthcare delivery.


Designing Change

American Association for the Advancement of Science: Visualizing Science Policy, 2013

Samantha explores the power of visual communication in healthcare by sharing her journey from traditional illustrator to "visual change-maker," drawing on her pivotal experiences with the RISD STEAM movement and her fellowship at the Mayo Clinic Center for Innovation.


Publications & Articles

Building Appropriate Mental Models: What Users Know and Want to Know about an Agentic AI Chatbot

ACM Conference on Intelligent User Interfaces (ACM IUI), March 2025

This study describes how users perceive and evaluate agentic AI systems revealing that they often lack a clear understanding of the underlying technology which creates the need for greater system transparency in the UX. Read here


Designing Ethics Tools for Self-Reflection, Collaboration, and Facilitation (book chapter)

Ethics In Design and Communication published by Bloomsbury Academic, 2019

Through a series of case studies and qualitative research, this chapter explores the evolution of the authors' tools for ethics and proposes a framework for how these resources empower designers to navigate ethical alignment through individual self-reflection, team collaboration, and organizational facilitation. Read the chapter


Designing Ethics: Shifting Ethical Understanding in Design

Smashing Magazine, Nov 2017

This article explores how designers can move beyond static manifestos to guide their ethics by using collaborative tools and games to facilitate ongoing, project-specific ethical conversations within interdisciplinary teams. Read here


A Designer's Oath: Collaboratively Designing a Code of Ethics for Design

Touchpoint Magazine, June 2015

This article introduces the Designer's Oath, a co-creative project connecting designers across the globe to collaboratively create a professional code inspired by the Hippocratic Oath. Learn more


How Designers Can Improve Healthcare For Everyone

Scientific American, March 2015

As an experience designer, I bridge the gap between clinical systems and human behavior by creating research-driven tools that empower both patients and care teams to achieve better health outcomes. Read here


Radical Collaborations

Metropolis Magazine, August 2012

As the first illustrator-in-residence at the Mayo Clinic Center for Innovation, I explore how art and empathetic storytelling can humanize and transform the future of healthcare. Read here


An Illustrator at the Mayo Clinic

Metropolis Magazine, August 2012

I share how I bridge the gap between art and medicine as an illustrator at the Mayo Clinic Center for Innovation by using visual storytelling, graphic facilitation, and animation to enhance patient communication and reimagine the healthcare experience. Read here


Press

The Designer’s Oath: Navigating Ethical Dilemmas in UX Design with Samantha and Ciara

DesignWhine, February 2025

In this interview, I draw on over a decade of experience to offer a collaborative framework that empowers designers to navigate complex moral landscapes and collectively build a more responsible and value-driven future. View here


Ethics in the Anthropology of Business (book referencing my work)

Routledge, 2017

My work is referenced in Chapter 6 of this book that bridges the gap between academic theory and corporate practice, drawing on unique anthropological perspectives to explore how ethical values can be meaningfully integrated into modern industry settings. View here


Let’s Talk Health Care Design: Samantha Dempsey

Designing Health, 2016

In this interview, I expand on my work at Hennepin County Medical Center, explaining how I blend co-creation and behavior change to design long-term solutions addressing social factors. View here


Sick of Selling Junkfood and False Promises, Designers Declare their own ‘Hippocratic Oath’

Quartz Magazine, 2015

This article describes how designers are increasingly championing the Designer's Oath to prioritize social responsibility and ethical practice over harmful commercial interests. View here


Empathy Boxes To Raise Awareness of Autism

Angelus News March, 2014

This article describes how students at Loyola High School took part in the Empathy Box Project (a project I co-founded) to foster autism awareness and meaningful social connection among their peers. View here


Artists and Scientists Observe, Ask Questions, Even Propose Solutions

American Association for the Advancement of Science, 2013

This article highlights collaborations between artists and scientists (including my own Extinction Empathy Tattoos project) that demonstrate how creative inquiry can spark vital dialogues on global policy and democracy. View here


These Tattoos Honor Lost, Not So Loved Species

Smithsonian Magazine September, 2013

This article celebrates my Extinction Tattoo Project that fosters public appreciation of non-charismatic extinct species making complex scientific topics both accessible and personally meaningful. View here

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